Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential
Identifieur interne : 000859 ( Main/Exploration ); précédent : 000858; suivant : 000860Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential
Auteurs : Sabrina Lusvarghi ; Carole A. BewleySource :
- Viruses [ 1999-4915 ] ; 2016.
Abstract
Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity against several enveloped viruses. GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. The potential to inhibit other viruses as well as parasites has also been demonstrated. Griffithsin’s antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. Here, we review structural and biochemical studies that established mode of action and facilitated construction of GRFT analogs, mechanisms that may lead to resistance, and in vitro and pre-clinical results that support the therapeutic potential of this lectin.
Url:
DOI: 10.3390/v8100296
PubMed: 27783038
PubMed Central: 5086628
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential</title><author><name sortKey="Lusvarghi, Sabrina" sort="Lusvarghi, Sabrina" uniqKey="Lusvarghi S" first="Sabrina" last="Lusvarghi">Sabrina Lusvarghi</name></author><author><name sortKey="Bewley, Carole A" sort="Bewley, Carole A" uniqKey="Bewley C" first="Carole A." last="Bewley">Carole A. Bewley</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27783038</idno><idno type="pmc">5086628</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086628</idno><idno type="RBID">PMC:5086628</idno><idno type="doi">10.3390/v8100296</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000803</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000803</idno><idno type="wicri:Area/Pmc/Curation">000803</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000803</idno><idno type="wicri:Area/Pmc/Checkpoint">000269</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000269</idno><idno type="wicri:Area/Ncbi/Merge">000582</idno><idno type="wicri:Area/Ncbi/Curation">000582</idno><idno type="wicri:Area/Ncbi/Checkpoint">000582</idno><idno type="wicri:Area/Main/Merge">000861</idno><idno type="wicri:Area/Main/Curation">000859</idno><idno type="wicri:Area/Main/Exploration">000859</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential</title><author><name sortKey="Lusvarghi, Sabrina" sort="Lusvarghi, Sabrina" uniqKey="Lusvarghi S" first="Sabrina" last="Lusvarghi">Sabrina Lusvarghi</name></author><author><name sortKey="Bewley, Carole A" sort="Bewley, Carole A" uniqKey="Bewley C" first="Carole A." last="Bewley">Carole A. Bewley</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity against several enveloped viruses. GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. The potential to inhibit other viruses as well as parasites has also been demonstrated. Griffithsin’s antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. Here, we review structural and biochemical studies that established mode of action and facilitated construction of GRFT analogs, mechanisms that may lead to resistance, and in vitro and pre-clinical results that support the therapeutic potential of this lectin.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Doms, R W" uniqKey="Doms R">R.W. Doms</name></author><author><name sortKey="Moore, J P" uniqKey="Moore J">J.P. Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrison, S C" uniqKey="Harrison S">S.C. Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burton, D R" uniqKey="Burton D">D.R. Burton</name></author><author><name sortKey="Poignard, P" uniqKey="Poignard P">P. Poignard</name></author><author><name sortKey="Stanfield, R L" uniqKey="Stanfield R">R.L. Stanfield</name></author><author><name sortKey="Wilson, I A" uniqKey="Wilson I">I.A. 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